how-does-the-sequential-model-knf-model-explain-the-sigmoidal-kinetics-of-allost

Question

How does the sequential model (KNF model) explain the sigmoidal kinetics of allosteric enzymes?

Accepted Answer

Subunits change conformation one at a time upon substrate binding.

Answer

Subunits do not change conformation.

Answer

All subunits change conformation simultaneously.

Answer

Subunits are permanently in the R state.