Which statement correctly differentiates between an apoenzyme and a holoenzyme?

An apoenzyme is active without its cofactor, while a holoenzyme is inactive with its cofactor.

A holoenzyme is inactive without its cofactor, while an apoenzyme is active with its cofactor.

Both apoenzymes and holoenzymes are active forms of enzymes.

An apoenzyme is inactive without its cofactor, while a holoenzyme is active with its cofactor.