Which of the following correctly describes the sequence of events in the insulin signaling cascade?

Insulin binds to RTK, RTK autophosphorylates, IRS 1 is phosphorylated, PI3K is activated, PIP2 is converted to PIP3, PKB is activated.

Insulin binds to RTK, RTK inhibits IRS 1, PI3K is phosphorylated, PIP3 is converted to PIP2, PKB is degraded.

Insulin binds to RTK, RTK activates IRS 1, PI3K is degraded, PIP2 is phosphorylated, PKB is inhibited.

Insulin binds to RTK, IRS 1 is degraded, PI3K is inhibited, PIP2 is hydrolyzed, PKB is inactivated.