Why can different enantiomers of a drug like thalidomide have drastically different biological effects?

Enantiomers have different solubility properties, affecting their distribution in the body.

Enantiomers have different atomic compositions, leading to different interactions with biological molecules.

Enantiomers have different 3D shapes, which can interact differently with chiral environments in the body.

Enantiomers have different melting points, which influence their biological activity.