a-mutation-in-phospholipase-c-plc-prevents-it-from-hydrolyzing-pip2-what-would-b

Question

A mutation in phospholipase C (PLC) prevents it from hydrolyzing PIP2. What would be the expected consequence in the signaling pathway?

Accepted Answer

No production of IP3 and DAG, leading to reduced calcium release and PKC activation.

Answer

Increased production of cAMP.

Answer

Increased activation of adenylate cyclase.

Answer

Enhanced activation of protein kinase A.