why-cant-pyruvate-be-directly-converted-to-phosphoenolpyruvate-in-gluconeogenesi

Question

Why can't pyruvate be directly converted to phosphoenolpyruvate in gluconeogenesis?

Accepted Answer

The reaction is too energetically favorable to be reversed in one step.

Answer

The conversion requires NADH.

Answer

Phosphoenolpyruvate is not a substrate for pyruvate kinase.

Answer

Pyruvate is an unstable molecule.