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What effect does methylation of CpG islands have on human promoters?
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16. Regulation of Expression
Eukaryotic Chromatin Modifications
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Histone acetylation is associated with:
A
Activate transcription in that region, RNA Polymerase can easily interact with DNA.
B
Repressed transcription in that region, RNA Polymerase cannot easily interact with DNA.
C
Tightly-packed nucleosomes.
D
No change in chromatin structure or transcription rates.
Guida verificata passo dopo passo1
Understand that histone acetylation is a post-translational modification where an acetyl group is added to the lysine residues of histone proteins.
Recognize that acetylation neutralizes the positive charge on histones, reducing their affinity for the negatively charged DNA.
Know that this reduction in affinity leads to a more relaxed chromatin structure, making DNA more accessible to transcription machinery.
Identify that with a more open chromatin structure, RNA Polymerase and other transcription factors can more easily bind to DNA, facilitating transcription.
Conclude that histone acetylation is generally associated with the activation of transcription in that region, as it allows RNA Polymerase to interact more easily with DNA.
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