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Ch. 48 - The Immune System in Animals
Freeman - Biological Science 8th Edition
Freeman8th EditionBiological ScienceISBN: 9780138276263Non è quello che usi tu?Cambia libro di testo
Capitolo 48, Problema 4

What is one of the differences between CD4+ and CD8+ T cells?
a. CD4+ cells are immature, and CD8+ cells are mature.
b. CD4+ cells are activated, and CD8+ cells are not.
c. CD4+ cells interact with class II MHC proteins, and CD8+ cells interact with class I MHC proteins.
d. CD4+ cells activate cell-mediated responses, and CD8+ cells activate humoral responses.

Guida verificata passo dopo passo
1
Understand the role of T cells in the immune system: T cells are a type of lymphocyte that play a central role in cell-mediated immunity. They are primarily involved in identifying and destroying infected cells.
Differentiate between CD4+ and CD8+ T cells: CD4+ T cells, also known as helper T cells, assist other cells in the immune response. CD8+ T cells, also known as cytotoxic T cells, directly attack and destroy infected cells.
Identify the interaction with MHC proteins: CD4+ T cells typically interact with antigens presented by class II Major Histocompatibility Complex (MHC) proteins, which are found on the surface of antigen-presenting cells. CD8+ T cells interact with antigens presented by class I MHC proteins, which are present on almost all nucleated cells.
Evaluate the options given in the problem: Option c states that CD4+ cells interact with class II MHC proteins, and CD8+ cells interact with class I MHC proteins. This aligns with the known functions and interactions of these T cell types.
Conclude which option correctly describes the difference: Based on the understanding of T cell interactions with MHC proteins, option c is the correct description of the difference between CD4+ and CD8+ T cells.

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T Cell Differentiation

T cells are a type of lymphocyte that play a central role in cell-mediated immunity. They differentiate into various subtypes, including CD4+ and CD8+ T cells, each with distinct functions. CD4+ T cells, also known as helper T cells, assist other cells in the immune response, while CD8+ T cells, or cytotoxic T cells, directly kill infected cells.
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Cell Division and Differentiation

Major Histocompatibility Complex (MHC)

MHC molecules are proteins found on the surfaces of cells that present antigens to T cells. There are two classes: MHC class I, which presents antigens to CD8+ T cells, and MHC class II, which presents antigens to CD4+ T cells. This interaction is crucial for the activation and function of T cells in the immune response.
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Major Histocompatibility Complex

Immune Response Activation

CD4+ and CD8+ T cells are involved in different types of immune responses. CD4+ T cells primarily activate and regulate other immune cells, including B cells and macrophages, facilitating the humoral and cell-mediated immune responses. CD8+ T cells are responsible for the direct killing of infected or cancerous cells, playing a key role in cell-mediated immunity.
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Innate Immune Response
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T/F The adaptive immune response uses receptors to recognize pathogens, and the innate immune response does not.

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d. The innate immune response does not kill cells; the adaptive immune response does.

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The overall role of the inflammatory response is to

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d. Increase blood flow at the site of a wound to flush out invading pathogens.

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