What is the role of PTEN phosphatase in phosphoinositide signaling pathways?

PTEN phosphatase removes phosphates from phosphoinositol lipids, inactivating the signaling pathway.

PTEN phosphatase inhibits protein kinase C, reducing calcium signaling.

PTEN phosphatase directly produces IP3 and DAG.

PTEN phosphatase adds phosphates to phosphoinositol lipids, activating the signaling pathway.