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If a cell suffers damage to its DNA while in S phase, how can this damage be repaired before the cell enters mitosis?
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Ch. 19 - The Genetics of Cancer
Klug10th EditionEssentials of GeneticsISBN: 9780135588789
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics16
- Ch. 2 - Mitosis and Meiosis28
- Ch. 3 - Mendelian Genetics37
- Ch. 4 - Modification of Mendelian Ratios53
- Ch. 5 - Sex Determination and Sex Chromosomes32
- Ch. 6 - Chromosome Mutations: Variation in Number and Arrangement37
- Ch. 7 - Linkage and Chromosome Mapping in Eukaryotes36
- Ch. 8 - Genetic Analysis and Mapping in Bacteria and Bacteriophages24
- Ch. 9 - DNA Structure and Analysis38
- Ch. 10 - DNA Replication29
- Ch. 11 - Chromosome Structure and DNA Sequence Organization22
- Ch. 12 - The Genetic Code and Transcription36
- Ch. 13 - Translation and Proteins27
- Ch. 14 - Gene Mutation, DNA Repair, and Transposition34
- Ch. 15 - Regulation of Gene Expression in Bacteria22
- Ch. 16 - Regulation of Gene Expression in Eukaryotes37
- Ch. 17 - Recombinant DNA Technology27
- Ch. 18 - Genomics, Bioinformatics, and Proteomics30
- Ch. 19 - The Genetics of Cancer21
- Ch. 20 - Quantitative Genetics and Multifactorial Traits37
- Ch. 21 - Population and Evolutionary Genetics45
Klug10th EditionEssentials of GeneticsISBN: 9780135588789Non è quello che usi tu?Cambia libro di testo
Capitolo 19, Problema 11
How does the p53 tumor-suppressor protein control cell-cycle checkpoints?
Guida verificata passo dopo passo1
Understand that the p53 protein is a tumor suppressor that plays a critical role in maintaining genomic stability by regulating the cell cycle.
Recognize that p53 functions primarily by acting as a transcription factor that can activate or repress the expression of genes involved in cell cycle arrest, DNA repair, and apoptosis.
Identify that when DNA damage or cellular stress is detected, p53 becomes stabilized and accumulates in the nucleus, where it can induce the expression of the gene encoding p21, a cyclin-dependent kinase inhibitor.
Know that p21 inhibits cyclin-CDK complexes, which are essential for progression through the G1/S checkpoint, thereby causing cell cycle arrest and allowing time for DNA repair.
Realize that if the damage is irreparable, p53 can also initiate programmed cell death (apoptosis) to prevent the propagation of damaged cells, thus controlling cell-cycle checkpoints and preventing tumor development.
Concetti chiave
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p53 Tumor-Suppressor Protein
p53 is a crucial protein that acts as a tumor suppressor by regulating the cell cycle and preventing the proliferation of damaged cells. It functions mainly as a transcription factor that can activate genes involved in DNA repair, cell cycle arrest, or apoptosis in response to cellular stress or DNA damage.
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05:05
Proteins
Cell-Cycle Checkpoints
Cell-cycle checkpoints are control mechanisms that ensure the proper progression of the cell cycle by verifying whether processes like DNA replication and chromosome segregation have been accurately completed. These checkpoints prevent the division of cells with damaged DNA, maintaining genomic stability.
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04:29Bacteriophage Life Cycle
Mechanism of p53-Mediated Cell-Cycle Arrest
Upon DNA damage, p53 is stabilized and activates the transcription of genes such as p21, which inhibits cyclin-dependent kinases (CDKs). This inhibition halts the cell cycle at the G1/S checkpoint, allowing time for DNA repair or triggering apoptosis if the damage is irreparable.
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05:34Bacteriophage Regulation
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