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What must be assumed in order to validate the answers in Problem 7?
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Ch. 26 - Population and Evolutionary Genetics
Klug12th EditionConcepts of GeneticsISBN: 9780135564776
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TOC.tableOfContents
- Ch. 1 - Introduction to Genetics17
- Ch. 2 - Mitosis and Meiosis36
- Ch. 3 - Mendelian Genetics51
- Ch. 4 - Extensions of Mendelian Genetics74
- Ch. 5 - Chromosome Mapping in Eukaryotes51
- Ch. 6 - Genetic Analysis and Mapping in Bacteria and Bacteriophages46
- Ch. 7 - Sex Determination and Sex Chromosomes33
- Ch. 8 - Chromosome Mutations: Variation in Number and Arrangement40
- Ch. 9 - Extranuclear Inheritance31
- Ch. 10 - DNA Structure and Analysis43
- Ch. 11 - DNA Replication and Recombination44
- Ch. 12 - DNA Organization in Chromosomes30
- Ch. 13 - The Genetic Code and Transcription54
- Ch. 14 - Translation and Proteins47
- Ch. 15 - Gene Mutation, DNA Repair, and Transposition41
- Ch. 16 - Regulation of Gene Expression in Bacteria29
- Ch. 17 - Transcriptional Regulation in Eukaryotes41
- Ch. 18 - Post-transcriptional Regulation in Eukaryotes33
- Ch. 19 - Epigenetics33
- Ch. 20 - Recombinant DNA Technology44
- Ch. 21 - Genomic Analysis36
- Ch. 22 - Applications of Genetic Engineering and Biotechnology36
- Ch. 23 - Developmental Genetics37
- Ch. 24 - Cancer Genetics34
- Ch. 25 - Quantitative Genetics and Multifactorial Traits54
- Ch. 26 - Population and Evolutionary Genetics45
Klug12th EditionConcepts of GeneticsISBN: 9780135564776Non è quello che usi tu?Cambia libro di testo
Capitolo 26, Problema 6c
Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
0.09
Guida verificata passo dopo passo1
Identify the given information: the frequency of individuals affected by the autosomal recessive disorder is 0.09. This frequency corresponds to the homozygous recessive genotype (q\^2) in the population.
Calculate the allele frequency of the recessive allele (q) by taking the square root of the affected frequency: \(q = \sqrt{0.09}\).
Determine the frequency of the dominant allele (p) using the relationship \(p + q = 1\), so \(p = 1 - q\).
Calculate the frequency of heterozygous carriers (the individuals with genotype Aa) using the Hardy-Weinberg formula for heterozygotes: \$2pq$.
Convert the frequency of heterozygous carriers to a percentage by multiplying the result by 100.
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Autosomal Recessive Inheritance
Autosomal recessive disorders require two copies of a mutant allele for the phenotype to be expressed. Individuals with only one mutant allele are carriers and typically do not show symptoms. Understanding this inheritance pattern is essential to relate genotype frequencies to disease prevalence.
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Percorso guidato
09:08
Autosomal Pedigrees
Hardy-Weinberg Equilibrium
The Hardy-Weinberg principle provides a mathematical framework to relate allele and genotype frequencies in a population under random mating and no evolutionary forces. It allows calculation of carrier frequencies from disease prevalence using p² + 2pq + q² = 1, where q² represents affected individuals.
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13:04Hardy Weinberg
Calculating Carrier Frequency from Disease Prevalence
For autosomal recessive disorders, the frequency of affected individuals (q²) is known, allowing calculation of q (mutant allele frequency). The carrier frequency is 2pq, where p ≈ 1 for rare disorders. This calculation estimates the percentage of heterozygous carriers in the population.
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03:03New Alleles and Migration
Pratica correlata
Domanda del libro di testo
Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
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Domanda del libro di testo
Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
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The use of nucleotide sequence data to measure genetic variability is complicated by the fact that the genes of many eukaryotes are complex in organization and contain 5' and 3' flanking regions as well as introns. Researchers have compared the nucleotide sequence of two cloned alleles of the γ-globin gene from a single individual and found a variation of 1 percent. Those differences include 13 substitutions of one nucleotide for another and three short DNA segments that have been inserted in one allele or deleted in the other. None of the changes takes place in the gene's exons (coding regions). Why do you think this is so, and should it change our concept of genetic variation?
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Domanda del libro di testo
Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
0.10
411
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Domanda del libro di testo
Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
0.0064
464
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