Which of the following best describes the orientation of antiparallel strands in DNA in terms of the 3' and 5' ends?

Both strands run from 3' to 5'.

One strand runs from 3' to 5'; the other from 5' to 3'.

Both strands run from 5' to 5'.

One strand runs from 5' to 3'; the other from 5' to 5'.