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Competitive Inhibitors of Metabolic Pathways
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Problema 1
Problema 2
Problema 3
Problema 4
Competitive Inhibitors of Metabolic Pathways
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28. Antimicrobial Drugs / Competitive Inhibitors of Metabolic Pathways / Problema 1
Problema 1
Which two enzymes (using their common biochemical names) correspond to the transcript's 'enzyme A' and 'enzyme B' in the folic acid pathway?
A
Enzyme A is dihydropteroate synthase (target of sulfonamides); enzyme B is dihydrofolate reductase (target of trimethoprim).
B
Enzyme A is folylpolyglutamate synthase and enzyme B is folate transporter enzyme; these two are the classical antibiotic targets within folate metabolism.
C
Enzyme A is thymidylate synthase and enzyme B is ribonucleotide reductase, as both are key folate-dependent enzymes targeted by sulfonamides and trimethoprim respectively.
D
Enzyme A is dihydrofolate reductase and enzyme B is dihydropteroate synthase, because the pathway is reversed in bacteria compared with eukaryotes.
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