How do rifamycins like rifampin inhibit bacterial RNA synthesis?

They inhibit tRNA synthetases, thereby depleting charged tRNAs and halting transcription because RNA polymerase requires charged tRNA to continue elongation.

They degrade ribosomal RNA directly, preventing ribosome assembly and indirectly stopping transcription.

They bind to the beta subunit of bacterial RNA polymerase and block the elongation of the nascent RNA chain.

They intercalate into DNA upstream of promoters preventing RNA polymerase from recognizing promoter sequences but do not bind the polymerase directly.