t-does-not-cause-misreading-which-class-is-the-new-drug-most-likely-to-belong-to

Question

A newly isolated antibiotic prevents aminoacyl-tRNA from entering the A site of a bacterial 30S ribosomal subunit but does not cause misreading. Which class is the new drug most likely to belong to?

Accepted Answer

Tetracyclines, because they bind 30S and sterically block tRNA binding to the A site.

Answer

Macrolides, because they prevent tRNA binding by obstructing the peptide exit tunnel on the 50S subunit.

Answer

Chloramphenicol, because it binds the 50S subunit and prevents tRNA from receiving peptide bonds by blocking aminoacyl-tRNA accommodation.

Answer

Aminoglycosides, because they bind the 30S subunit and cause strong inhibition of tRNA entry by inducing mRNA cleavage.