What is the difference between upstream and downstream in relation to transcription?

Upstream sequences are located within the gene body, while downstream sequences are outside the gene body.

Downstream sequences are in the direction of transcription, while upstream sequences are in the opposite direction.

Upstream sequences are involved in transcription initiation, while downstream sequences are involved in transcription termination.

Downstream sequences are part of the coding region, while upstream sequences are part of the non-coding region.