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Ch. 20 - Pathogenic Gram-Negative Cocci and Bacilli
Bauman - Microbiology with Diseases by Taxonomy 6th Edition
Bauman6th EditionMicrobiology with Diseases by TaxonomyISBN: 9780134832302Non è quello che usi tu?Cambia libro di testo
Capitolo 20, Problema 6

Capsules of pathogenic enteric bacteria are virulence factors because they __________.
a. Capture iron from hemoglobin and store it in the bacteria
b. Release hemolysins that destroy red blood cells
c. Produce fimbriae that enable the bacteria to attach to human cells
d. Protect the bacteria from phagocytosis and from some antibodies

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1
Understand what a capsule is: it is a polysaccharide layer that surrounds some bacteria, providing protection and aiding in virulence.
Recall the role of capsules in pathogenic bacteria, especially enteric bacteria, which are bacteria that inhabit the intestinal tract.
Consider how capsules help bacteria evade the host immune system, particularly by preventing phagocytosis, which is the process where immune cells engulf and destroy bacteria.
Evaluate each option in the question by matching it with known functions of capsules: iron capture, hemolysin release, fimbriae production, and protection from immune responses.
Identify that capsules primarily protect bacteria from phagocytosis and some antibodies, making option (d) the correct explanation of their role as virulence factors.

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Bacterial Capsules as Virulence Factors

Capsules are protective layers surrounding some bacteria that enhance their ability to cause disease. They help bacteria evade the host immune system by preventing phagocytosis, allowing the bacteria to survive and multiply within the host.
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Phagocytosis and Immune Evasion

Phagocytosis is a process where immune cells engulf and destroy pathogens. Capsules interfere with this process by masking bacterial surface antigens, making it harder for immune cells to recognize and ingest the bacteria, thus aiding bacterial survival.
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Role of Antibodies in Bacterial Clearance

Antibodies bind to bacterial antigens to mark them for destruction. Capsules can inhibit antibody binding or complement activation, reducing the effectiveness of the immune response and allowing bacteria to persist in the host.
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Antibodies