Skip to main content
Ch. 18 - Practical Applications of Immunology
Tortora - Microbiology: An Introduction 14th Edition
Tortora14th EditionMicrobiology: An IntroductionISBN: 9780138200398Non è quello che usi tu?Cambia libro di testo
Tutti i libri di testoTortora 14th EditionCh. 18 - Practical Applications of ImmunologyProblema 10
Capitolo 14, Problema 10

A purified protein from Mycobacterium tuberculosis is injected into a person’s skin. A hardened, red area develops around the injection site within 3 days.

Guida verificata passo dopo passo
1
Identify the type of immune response described: a purified protein from Mycobacterium tuberculosis is injected intradermally, and a localized hardened, red area develops within 3 days. This suggests a delayed-type hypersensitivity reaction.
Recall that the test described is the Tuberculin Skin Test (TST), also known as the Mantoux test, which is used to detect prior sensitization to Mycobacterium tuberculosis.
Understand that the reaction is mediated by T cells (specifically Th1 cells) that recognize the protein antigen and recruit macrophages, leading to inflammation and induration (hardening).
Name the test based on this immunological principle: it is called the Tuberculin Skin Test or Mantoux test.
Summarize that the observed reaction is a classic example of a Type IV hypersensitivity reaction, which is cell-mediated and typically appears 48-72 hours after antigen exposure.

Risposta video verificata per un problema simile:

Questa soluzione video è stata consigliata dai nostri tutor come utile per risolvere questo problema.
Durata del video:
2m

Concetti chiave

Ecco i concetti essenziali che devi comprendere per rispondere correttamente alla domanda.

Tuberculin Skin Test (Mantoux Test)

The tuberculin skin test involves injecting a purified protein derivative (PPD) from Mycobacterium tuberculosis into the skin to detect prior exposure. A localized immune reaction causing redness and induration within 48-72 hours indicates a positive test, reflecting a cell-mediated immune response.
Video consigliato:
06:59
The Ames Test

Delayed-Type Hypersensitivity (Type IV Hypersensitivity)

This immune response is mediated by T cells rather than antibodies and occurs 24-72 hours after antigen exposure. In the tuberculin test, sensitized T cells recognize the injected protein, releasing cytokines that recruit macrophages and cause localized inflammation and tissue hardening.
Video consigliato:
01:06
Types of Phosphorylation

Cell-Mediated Immunity in Tuberculosis

Cell-mediated immunity is crucial for controlling Mycobacterium tuberculosis infection. Sensitized T helper cells activate macrophages to contain the bacteria, and this immune memory is the basis for the skin test reaction, indicating prior sensitization to the pathogen.
Video consigliato:
03:27
Introduction to Cells of the Immune System
Pratica correlata
Domanda del libro di testo

In an agglutination test, eight serial dilutions to determine antibody titer were set up: Tube 1 contained a 1:2 dilution; tube 2, a 1:4, and so on. If tube 5 is the last tube showing agglutination, what is the antibody titer?

a. 5

b. 1:5

c. 32

d. 1:32

1553
views
Domanda del libro di testo

Test used to detect the presence of antibodies in a patient’s serum.

a. Direct fluorescent antibody

b. Indirect fluorescent antibody

c. Rabies immune globulin

d. Killed rabies virus

e. None of the above

791
views
Domanda del libro di testo

Match each of the following tests in column A to its positive reaction in column B.

1440
views