a-new-therapy-specifically-reduces-hepatic-vldl-secretion-by-25-over-the-long-te

Question

A new therapy specifically reduces hepatic VLDL secretion by 25% over the long term. Which outcome would most plausibly follow and provide the best rationale based on lipoprotein metabolism?

Accepted Answer

LDL concentrations will likely decrease over time because less VLDL substrate is available for conversion, thereby reducing atherosclerotic risk.

Answer

Triglycerides in adipose tissue will immediately rise to infinity because VLDL export is the only pathway for triglyceride mobilization.

Answer

HDL concentrations will necessarily double because HDL is produced exclusively from VLDL particles.

Answer

There will be no possible effect on LDL or atherosclerotic risk because VLDL and LDL are produced in separate, unrelated pathways.