Which stepwise experimental program would best support a company's GRAS determination for a novel sweetener (choose the most complete sequence)?

Compile published independent animal/toxicology studies, develop validated analytical detection methods for the compound in foods, assemble expert consensus reviews, and publish the findings for transparency — aligns with GRAS criteria and addresses detection and safety concerns

Submit no safety data but provide marketing studies showing that consumers prefer the taste and therefore implicitly accept the additive, which the FDA treats as sufficient evidence for GRAS

Only perform analytical testing to show the compound can be measured in foods and skip toxicology because detectability automatically proves safety under GRAS

Begin immediate mass production and marketing under a self-affirmed GRAS claim and rely on consumer feedback to detect any safety signals because historical use need not be documented