a-genetic-mutation-reduces-expression-of-a-sodium-dependent-glucose-transporter-

Question

A genetic mutation reduces expression of a sodium-dependent glucose transporter on enterocytes. Which combination of immediate absorption change and downstream systemic effect is most likely?

Accepted Answer

Reduced active glucose uptake from the lumen leading to decreased postprandial portal glucose delivery and potential hypoglycemia between meals if compensatory mechanisms fail.

Answer

Increased passive diffusion of glucose across the lipid bilayer that fully compensates, so no change in systemic glucose levels would be observed.

Answer

Enhanced fat absorption due to channel cross-activation, causing hyperlipidemia and no effect on glucose handling.

Answer

Immediate diversion of all dietary glucose to lacteals and lymphatics resulting in elevated chylomicron-associated glucose concentrations in peripheral tissues.