Which brief statement correctly contrasts manganese and magnesium based on the lesson?

Magnesium has no enzymatic roles and functions only as an inert structural mineral, while manganese regulates blood pH directly and is required in gram amounts daily.

Manganese and magnesium are chemically identical in biological systems, and therefore interchangeable in dietary recommendations and toxicity profiles across all populations.

Manganese is a vitamin and needs to be synthesized by gut bacteria, while magnesium is exclusively obtained from animal products and has no role in metabolism.

Both manganese and magnesium act as enzyme cofactors in metabolism; magnesium is a major mineral and electrolyte whereas manganese is a trace mineral (RDA ~1.8–2.3 mg) and toxic only at very high doses or in industrial exposures.