Which combination of observed signs would most strongly indicate alcohol poisoning rather than a simple hangover?

Improved mood and increased talkativeness the next morning, indicating severe systemic toxicity that usually only resolves with chelation therapy.

Mild headache, thirst, and slight fatigue that improve after water and rest, as these are classic signs of alcohol poisoning requiring hospitalization.

Unconsciousness or inability to wake, repeated vomiting with inability to protect airway, and markedly slow or irregular breathing—these indicate alcohol poisoning and need emergency care.

Sustained alertness with normal gait and only a transient headache, which is pathognomonic for alcohol poisoning and mandates liver biopsy.