where-in-the-cell-does-pyruvate-conversion-to-acetylcoa-occur-under-aerobic-cond

Question

Where in the cell does pyruvate conversion to acetyl‑CoA occur under aerobic conditions, enabling entry into the citric acid cycle?

Accepted Answer

Inside the mitochondria (mitochondrial matrix), via the pyruvate dehydrogenase complex.

Answer

In the extracellular space where pyruvate is oxidized by plasma enzymes before re-entering muscle cells for the TCA cycle.

Answer

Within the sarcoplasmic reticulum where acetyl‑CoA is stored until needed for anaerobic glycolysis.

Answer

In the rough endoplasmic reticulum by ribosomal enzymes that synthesize acetyl‑CoA directly from pyruvate.