Red blood cells are placed into a hypertonic saline solution (higher solute concentration than inside the cells). What will occur and why?

Water will move out of the RBCs into the surrounding solution, causing the cells to shrink (crenate) because water follows the higher extracellular solute concentration

Solutes will diffuse into the RBCs through the membrane lowering intracellular osmolarity and thereby drawing additional water into the cells until both compartments have equal solute content

There will be no net water movement because osmotic pressure is always perfectly counterbalanced by hydrostatic pressure in isolated cell suspensions

Water will move into the RBCs causing them to swell and potentially lyse because cells always take on water when placed in any solution that contains electrolytes