a-genetic-mutation-severely-reduces-hemoglobins-ability-to-bind-oxygen-but-does-

Question

A genetic mutation severely reduces hemoglobin's ability to bind oxygen but does not affect red blood cell count. Which immediate physiological effect is most likely?

Accepted Answer

Tissue hypoxia with increased lactic acid production in affected tissues due to insufficient oxygen delivery despite normal RBC numbers

Answer

Excessive clotting and thrombosis since hemoglobin directly activates clotting factors when oxygen saturation drops

Answer

Hypervolemia from increased plasma retention because hemoglobin directly controls blood volume through oncotic pressure

Answer

Immediate renal failure because hemoglobin unable to bind oxygen will directly damage kidney tubular cells before other tissues are affected