why-might-a-drug-target-the-major-groove-of-the-dna-double-helix-instead-of-the-

Question

Why might a drug target the major groove of the DNA double helix instead of the minor groove?

Accepted Answer

The major groove provides more space for interaction and binding.

Answer

The minor groove is more protected by the DNA backbone.

Answer

The major groove is less stable and easier to disrupt.

Answer

The minor groove has more hydrogen bonds to break.