combine-the-steps-of-nucleophilic-acyl-substitution-to-illustrate-the-full-mecha

Question

Combine the steps of nucleophilic acyl substitution to illustrate the full mechanism of thioester hydrolysis.

Accepted Answer

Protonation, nucleophilic attack, tetrahedral intermediate formation, leaving group formation, deprotonation.

Answer

Nucleophilic attack, protonation, leaving group formation.

Answer

Nucleophilic attack, deprotonation, proton transfer.

Answer

Protonation, leaving group formation, nucleophilic attack.