How does the cellular location of PRRs influence their ability to detect MAMPs and DAMPs?

PRRs are not influenced by their cellular location for detection.

PRRs on the cell surface detect extracellular MAMPs, while those inside cells detect intracellular MAMPs and DAMPs.

Only endosomal PRRs detect DAMPs.

All PRRs detect only extracellular MAMPs regardless of their location.