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Immune Tolerance definitions
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Immune Tolerance
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Immune Tolerance
The immune system's ability to ignore harmless antigens while targeting harmful ones, preventing autoimmune diseases.
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이 집합의 용어 (15)
하이드의 정의
Immune Tolerance
The immune system's ability to ignore harmless antigens while targeting harmful ones, preventing autoimmune diseases.
Autoimmune Diseases
Conditions where the immune system mistakenly attacks the body's own healthy cells.
Central Immune Tolerance
Occurs in primary lymphoid organs, eliminating self-reacting cells through negative selection.
Peripheral Immune Tolerance
Occurs in secondary lymphoid organs, involving both positive and negative selection of mature immune cells.
Negative Selection
Elimination of immune cells that react to self or harmless antigens, preventing autoimmune responses.
Positive Selection
Promotion of immune cells that bind to MHC, ensuring they can recognize antigens properly.
Primary Lymphoid Organs
Sites like the thymus and bone marrow where immune cells develop and undergo central tolerance.
Secondary Lymphoid Organs
Locations such as lymph nodes where mature immune cells undergo peripheral tolerance.
Self-reacting Cells
Immune cells that mistakenly target the body's own healthy cells, leading to potential harm.
Apoptosis
Programmed cell death used to eliminate self-reacting or improperly functioning immune cells.
MHC
Molecules on cell surfaces that help the immune system recognize foreign substances.
Anergy
A state of unresponsiveness in immune cells that prevents them from attacking self-antigens.
Adaptive Immune System
The part of the immune system that learns to recognize and remember specific pathogens.
Pathogens
Harmful organisms or substances that can cause disease, targeted by the immune system.
Microbiota
The community of harmless microorganisms living in and on the human body, tolerated by the immune system.