Which statement best describes the difference between Michaelis-Menten and allosteric enzymes in negative feedback regulation?

Michaelis-Menten enzymes are regulated by substrate concentration, while allosteric enzymes are regulated by product concentration.

Allosteric enzymes are always more efficient than Michaelis-Menten enzymes.

Allosteric enzymes bind substrates at the active site only.

Michaelis-Menten enzymes are not involved in feedback regulation.