Which of the following statements correctly compares metalloenzymes and activator ions?

Both metalloenzymes and activator ions have tightly bound transition metals.

Both metalloenzymes and activator ions have loosely bound alkali metals.

Metalloenzymes have loosely bound alkali metals, while activator ions are tightly bound transition metals.

Metalloenzymes have tightly bound transition metals, while activator ions are loosely bound alkali metals.