why-is-it-important-to-use-pka-values-specific-to-amino-acid-residues-when-calcu

Question

Why is it important to use pKa values specific to amino acid residues when calculating the isoelectric point of a peptide?

Accepted Answer

Because the microenvironment in peptides can shift pKa values compared to free amino acids.

Answer

Because pKa values are irrelevant for free amino acids.

Answer

Because free amino acids do not have pKa values.

Answer

Because peptide bonds alter the chemical structure of amino acids.