Synthesize the role of phospholipase C in the phosphoenacitide GPCR signaling pathway and its effect on PIP2.

Phospholipase C binds to calcium ions to activate calmodulin.

Phospholipase C converts PIP2 into ATP.

Phospholipase C hydrolyzes PIP2 to produce IP3 and DAG, which act as secondary messengers in the signaling pathway.

Phospholipase C phosphorylates PIP2 to activate PKC.