In a cell signaling pathway, IP3 is produced and diffuses into the cytoplasm. What is the next step in this pathway?

IP3 is converted back into PIP2 in the cytoplasm.

IP3 binds to the cell membrane to initiate endocytosis.

IP3 binds to calcium channels on the endoplasmic reticulum, causing them to open and release calcium ions into the cytoplasm.

IP3 directly activates protein kinase C in the cytoplasm.