Which of the following sequences correctly describes the insulin signaling pathway via RTKs?

Insulin binds to RTK, IP3 is produced, calcium is released, leading to increased glucose metabolism

Insulin binds to RTK, DAG is produced, PKC is activated, leading to increased glycogen synthesis

Insulin binds to RTK, IRS-1 is phosphorylated, PI3K is activated, leading to increased GLUT4 expression

Insulin binds to RTK, cAMP is produced, PKA is activated, leading to increased glucose uptake