why-does-the-slope-of-the-lineweaver-burk-plot-remain-unchanged-in-the-presence-

Question

Why does the slope of the Lineweaver-Burk plot remain unchanged in the presence of uncompetitive inhibitors?

Accepted Answer

Because both Km and Vmax are proportionally decreased, keeping the Km/Vmax ratio constant.

Answer

Because the inhibitor only affects the free enzyme.

Answer

Because the substrate concentration is not affected.

Answer

Because uncompetitive inhibitors do not affect enzyme kinetics.