Question 1

Which protein in the replisome complex is primarily responsible for unwinding the DNA double helix during replication, as shown in the provided image?

Accepted Answer

Helicase (with CTD and NTD domains)

Question 2

In the context of eukaryotic DNA replication, what is the main function of Polymerase Epsilon as depicted in the image?

Accepted Answer

Synthesizes the leading strand continuously in the 5' to 3' direction

Question 3

Which protein in the replisome complex is responsible for synthesizing the lagging strand, and what is the nature of this synthesis?

Accepted Answer

Polymerase Alpha; discontinuous synthesis in short fragments

Question 4

What is the role of the Ctf4 protein in the replisome complex as shown in the image?

Accepted Answer

Holds the replisome complex together

Question 5

During DNA replication, which strand is synthesized continuously and which is synthesized discontinuously, as illustrated in the image?

Accepted Answer

Leading strand is synthesized continuously; lagging strand is synthesized discontinuously

Question 6

Which domain of the helicase protein is responsible for unwinding the DNA, as labeled in the image?

Accepted Answer

NTD (Amino Terminal Domain)

Question 7

If the function of Ctf4 is disrupted in the replisome, what is the most likely consequence for DNA replication?

Accepted Answer

The replisome complex will lose structural integrity, affecting coordination of replication

Question 8

Which of the following best describes the synthesis of Okazaki fragments during DNA replication?

Accepted Answer

They are synthesized on the lagging strand by Polymerase Alpha

Question 9

In the replisome complex, which protein is directly involved in the continuous synthesis of DNA, and in which direction does this synthesis occur?

Accepted Answer

Polymerase Epsilon; 5' to 3' direction

Question 10

Which of the following statements about the replisome complex is correct based on the image and study materials?

Accepted Answer

Helicase unwinds DNA, Polymerase Epsilon synthesizes the leading strand, Polymerase Alpha synthesizes the lagging strand, and Ctf4 holds the complex together.

Chapter 22 Review: DNA Replication – Key Concepts and Mechanisms

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