Question 1

Which of the following best describes the mechanism by which GLUT1 transports glucose across the erythrocyte membrane?

Accepted Answer

It undergoes a conformational change to move glucose down its concentration gradient.

Question 2

Which of the following is TRUE regarding the chloride shift in erythrocytes?

Accepted Answer

Chloride ions move into red blood cells in the tissues.

Question 3

What is the primary biological role of GLUT1 in erythrocytes?

Accepted Answer

To allow glucose to equilibrate across the membrane via facilitated diffusion.

Question 4

Which of the following steps occurs FIRST during erythrocyte glucose transport by GLUT1?

Accepted Answer

Glucose binds to the transporter on one side of the membrane.

Question 5

Which of the following statements about the chloride-bicarbonate exchanger is FALSE?

Accepted Answer

It requires ATP to function.

Question 6

In the tissues, what is the direction of chloride ion movement during the chloride shift?

Accepted Answer

Chloride ions move into the erythrocyte.

Question 7

Which of the following best explains why the chloride shift is necessary in erythrocytes?

Accepted Answer

To maintain electrical neutrality as bicarbonate ions are transported out of the cell.

Question 8

Which process is responsible for the majority of CO$$_2$$ transport from tissues to lungs?

Accepted Answer

Conversion of CO$$_2 to $$HCO$$_3^- in $$erythrocytes.

Question 9

Which of the following is a direct consequence of the chloride shift in the lungs?

Accepted Answer

Bicarbonate ions move into erythrocytes.

Question 10

Which of the following best describes the type of membrane transport used by GLUT1?

Accepted Answer

Facilitated diffusion

Question 11

A patient with a mutation in the GLUT1 gene is most likely to experience which of the following symptoms?

Accepted Answer

Decreased glucose uptake into erythrocytes, leading to reduced cellular energy.

Question 12

Which of the following correctly matches the transporter with its biological role?

Accepted Answer

GLUT1: Facilitated diffusion of glucose

Question 13

Which of the following events occurs during the chloride shift in the tissues?

Accepted Answer

CO$$_2$$ enters the erythrocyte and is converted to HCO$$_3^-.$$

Question 14

Which of the following is NOT a function of the chloride shift?

Accepted Answer

Increasing plasma pH by excreting HCO$$_3^-$$ via the kidneys.

Question 15

Which of the following best describes the direction of bicarbonate movement in the lungs during the chloride shift?

Accepted Answer

Bicarbonate moves into erythrocytes from plasma.

Erythrocyte Facilitated Transporter Models: Glucose and Chloride-Bicarbonate Exchange

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