Q: Which of the following equations correctly represents the overall reaction of glycolysis?

$$\text{Glucose} + 2\,\text{NAD}^+ + 2\,\text{ADP} + 2\,\text{P}_i \rightarrow 2\,\text{Pyruvate} + 2\,\text{NADH} + 2\,\text{ATP} + 2\,\text{H}_2\text{O}$$

Question 1

Which of the following is a primary function of glycolysis in cellular metabolism?

Accepted Answer

To break down glucose and produce ATP and NADH

Question 2

During the energy investment phase of glycolysis, how many ATP molecules are consumed per molecule of glucose?

Accepted Answer

$$2$$

Question 3

Which molecule is the final product of glycolysis?

Accepted Answer

Pyruvate

Question 4

In the energy payoff phase of glycolysis, how many NADH molecules are produced per molecule of glucose?

Accepted Answer

$$2$$

Question 5

Which of the following best describes the net ATP gain from glycolysis per molecule of glucose?

Accepted Answer

$$2$$

Question 6

Which step in glycolysis involves the conversion of NAD$$^+ to $$NADH?

Accepted Answer

Energy payoff phase

Question 7

If a cell is deprived of NAD$$^+$$, which phase of glycolysis would be directly affected?

Accepted Answer

Energy payoff phase

Question 8

Which of the following equations correctly represents the overall reaction of glycolysis?

Accepted Answer

$$	ext{Glucose} + 2\,	ext{NAD}^+ + 2\,	ext{ADP} + 2\,	ext{P}_i ightarrow 2\,	ext{Pyruvate} + 2\,	ext{NADH} + 2\,	ext{ATP} + 2\,	ext{H}_2	ext{O}$$

Question 9

Which of the following statements about glycolysis is FALSE?

Accepted Answer

Glycolysis requires oxygen to proceed.

Question 10

A patient with a genetic defect in the enzyme that catalyzes the first phosphorylation step of glycolysis would most likely have trouble with which process?

Accepted Answer

Phosphorylating glucose to glucose-6-phosphate

Question 11

Which phase of glycolysis is responsible for the net production of ATP?

Accepted Answer

Energy payoff phase

Question 12

If a mutation caused the cell to skip the energy investment phase of glycolysis, what would be the most likely consequence?

Accepted Answer

No glucose would be phosphorylated, halting glycolysis.

Question 13

Which of the following is NOT a direct product of glycolysis?

Accepted Answer

CO$$_2$$

Question 14

During glycolysis, which molecule acts as an electron acceptor?

Accepted Answer

NAD$$^+$$

Question 15

Which of the following best explains why glycolysis is considered an anaerobic process?

Accepted Answer

It does not require oxygen to generate ATP.

Question 16

A researcher measures the ATP yield from glycolysis in a sample of muscle cells. If the initial glucose concentration is doubled, what is the expected change in net ATP production?

Accepted Answer

It will double.

Question 17

Which of the following steps in glycolysis is irreversible under physiological conditions?

Accepted Answer

Phosphorylation of glucose to glucose-6-phosphate

Question 18

In a patient with a deficiency in the enzyme that converts phosphoenolpyruvate to pyruvate, which of the following would most likely accumulate?

Accepted Answer

Phosphoenolpyruvate

Question 19

Which of the following is a correct statement about the fate of pyruvate produced in glycolysis under aerobic conditions?

Accepted Answer

It is converted to acetyl-CoA and enters the citric acid cycle.

Question 20

Which of the following best describes substrate-level phosphorylation in glycolysis?

Accepted Answer

Direct transfer of a phosphate group from a substrate to ADP to form ATP

Glycolysis: Pathway, Phases, and Energy Yield

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