Q: Which of the following equations correctly represents the net reaction of glycolysis?

$$\text{Glucose} + 2\,\text{NAD}^+ + 2\,\text{ADP} + 2\,\text{P}_i \rightarrow 2\,\text{Pyruvate} + 2\,\text{NADH} + 2\,\text{ATP} + 2\,\text{H}_2\text{O}$$

Question 1

Which of the following best describes the two distinct phases of glycolysis?

Accepted Answer

An energy-investment phase and an energy-generation phase

Question 2

During the energy-investment phase of glycolysis, how many ATP molecules are consumed per molecule of glucose?

Accepted Answer

$$2$$

Question 3

Which enzyme catalyzes the phosphorylation of glucose to glucose-6-phosphate in the first step of glycolysis?

Accepted Answer

Hexokinase

Question 4

What is the net ATP yield from glycolysis per molecule of glucose under anaerobic conditions?

Accepted Answer

$$2$$

Question 5

Which of the following reactions in glycolysis is considered a major regulatory (control) point?

Accepted Answer

Phosphofructokinase

Question 6

In the energy-generation phase of glycolysis, which molecule is directly responsible for substrate-level phosphorylation to produce ATP?

Accepted Answer

1,3-Bisphosphoglycerate

Question 7

Which enzyme catalyzes the conversion of phosphoenolpyruvate (PEP) to pyruvate, generating ATP?

Accepted Answer

Pyruvate kinase

Question 8

What is the role of NAD+ in glycolysis?

Accepted Answer

It serves as an electron acceptor during the oxidation of glyceraldehyde-3-phosphate

Question 9

Which of the following is TRUE regarding the fate of pyruvate under anaerobic conditions in muscle cells?

Accepted Answer

Pyruvate is reduced to lactate to regenerate NAD+

Question 10

Which step in glycolysis involves the isomerization of glucose-6-phosphate to fructose-6-phosphate?

Accepted Answer

Step 2, catalyzed by glucose-6-phosphate isomerase

Question 11

Which of the following best explains why the overall glycolytic pathway is exergonic?

Accepted Answer

Because the conversion of phosphoenolpyruvate to pyruvate is highly exergonic due to spontaneous tautomerization

Question 12

Which enzyme in glycolysis is allosterically inhibited by ATP and activated by AMP?

Accepted Answer

Phosphofructokinase

Question 13

If a mutation rendered phosphoglycerate kinase inactive, which of the following would be the most direct consequence?

Accepted Answer

No ATP would be produced from 1,3-bisphosphoglycerate

Question 14

Which of the following equations correctly represents the net reaction of glycolysis?

Accepted Answer

$$	ext{Glucose} + 2\,	ext{NAD}^+ + 2\,	ext{ADP} + 2\,	ext{P}_i ightarrow 2\,	ext{Pyruvate} + 2\,	ext{NADH} + 2\,	ext{ATP} + 2\,	ext{H}_2	ext{O}$$

Question 15

Which glycolytic intermediate is the first to contain two phosphate groups?

Accepted Answer

Fructose-1,6-bisphosphate

Question 16

Which enzyme catalyzes the reversible cleavage of fructose-1,6-bisphosphate into two triose phosphates?

Accepted Answer

Aldolase

Question 17

During glycolysis, which step involves the oxidation of an aldehyde to a carboxylic acid while reducing NAD$$^+ to $$NADH?

Accepted Answer

Glyceraldehyde-3-phosphate dehydrogenase

Question 18

Which of the following statements about substrate-level phosphorylation in glycolysis is CORRECT?

Accepted Answer

It directly generates ATP from ADP and a high-energy phosphate compound

Question 19

Which glycolytic enzyme is responsible for the conversion of 2-phosphoglycerate to phosphoenolpyruvate?

Accepted Answer

Enolase

Question 20

A patient presents with a deficiency in triose phosphate isomerase. Which glycolytic intermediate would most likely accumulate?

Accepted Answer

Dihydroxyacetone phosphate

Glycolysis: Pathway, Phases, and Key Reactions

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