Question 1

Which of the following best describes the role of 6-phosphogluconate in cellular metabolism?

Accepted Answer

It is an intermediate in the pentose phosphate pathway.

Question 2

During anaerobic muscle metabolism, lactate is formed from glucose. If glucose labeled at carbon-2 is metabolized, which carbon of lactate will be labeled?

Accepted Answer

Carbon 2

Question 3

Glycogen is considered a non-reducing sugar because:

Accepted Answer

Its terminal glucose residues are not free aldehydes.

Question 4

Which enzyme catalyzes the conversion of dihydroxyacetone phosphate to glyceraldehyde-3-phosphate in glycolysis?

Accepted Answer

Triose phosphate isomerase

Question 5

Which of the following glycolytic reactions is considered irreversible under physiological conditions?

Accepted Answer

Pyruvate kinase

Question 6

In the pentose phosphate pathway, which enzyme catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose-5-phosphate?

Accepted Answer

6-phosphogluconate dehydrogenase

Question 7

Which of the following best explains why glycolysis can proceed in the absence of oxygen?

Accepted Answer

NAD+ is regenerated by the reduction of pyruvate to lactate.

Question 8

Which of the following is the correct net equation for glycolysis?

Accepted Answer

$$\mathrm{Glucose + 2NAD^+ + 2ADP + 2P_i \rightarrow 2Pyruvate + 2NADH + 2ATP + 2H_2O + 2H^+}$$

Question 9

Which glycolytic enzyme is allosterically inhibited by ATP and activated by AMP?

Accepted Answer

Phosphofructokinase-1

Question 10

A patient with a deficiency in triose phosphate isomerase would most likely accumulate which glycolytic intermediate?

Accepted Answer

Dihydroxyacetone phosphate

Question 11

Which of the following best describes the fate of pyruvate under anaerobic conditions in human muscle?

Accepted Answer

It is converted to lactate.

Question 12

Which enzyme catalyzes the phosphorylation of glucose to glucose-6-phosphate in the first step of glycolysis?

Accepted Answer

Hexokinase

Question 13

Which of the following statements about the pentose phosphate pathway is correct?

Accepted Answer

It generates ribose-5-phosphate for nucleotide synthesis.

Question 14

Which glycolytic intermediate is a substrate for the enzyme aldolase?

Accepted Answer

Fructose-1,6-bisphosphate

Question 15

Which of the following reactions in glycolysis is coupled to the reduction of NAD+ to NADH?

Accepted Answer

$$\mathrm{Glyceraldehyde-3-phosphate \rightarrow 1,3-bisphosphoglycerate}$$

Key Concepts in Glycolysis and Carbohydrate Metabolism

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