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Proteins, Carbohydrates, and Lipids: Structures and Functions in Living Systems

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Proteins, Carbohydrates, and Lipids

3.1 What Kinds of Molecules Characterize Living Things?

Living organisms are composed of a variety of large, complex molecules known as macromolecules. These macromolecules are essential for structure, function, and information storage in cells.

  • Proteins: Provide structure and catalyze biochemical reactions.

  • Carbohydrates: Serve as energy sources and provide structural support.

  • Lipids: Form cell membranes and store energy.

  • Nucleic acids: Store and transmit genetic information (DNA and RNA).

Most macromolecules are polymers, which are large molecules made up of repeating smaller units called monomers. For example, proteins are polymers of amino acids, and carbohydrates are polymers of simple sugars.

Macromolecules and Their Functions

  • Macromolecules: Polymers with molecular weights typically greater than 1,000.

  • They form the backbone of living organisms and are crucial to biological functions.

Types of Macromolecules

  • Proteins: Structure, catalysis (enzymes).

  • Nucleic Acids: Genetic information storage (DNA/RNA).

  • Carbohydrates: Energy, structural support.

  • Lipids: Membranes, energy storage.

Functional Groups in Biological Molecules

The function of a biological molecule is determined by its functional groups—specific clusters of atoms that impart characteristic chemical properties and reactivity.

  • Hydroxyl Group (-OH): Increases hydrophilicity (water solubility).

  • Carboxyl Group (-COOH): Confers acidic properties.

  • Amino Group (-NH2): Confers basic properties; essential in amino acids.

  • Phosphate Group (-PO4): Involved in energy transfer (e.g., ATP), key in nucleic acids.

Many macromolecules contain multiple functional groups, enabling complex chemical functions.

Some Functional Groups Important to Living Systems

Functional group

Class of compounds and an example

Properties

Hydroxyl (-OH)

Alcohols (e.g., Ethanol)

  • Polar due to the electronegativity of oxygen.

  • Forms hydrogen bonds with water, increasing solubility of organic molecules.

  • Enables molecules to link via condensation reactions.

Carbonyl (C=O)

Aldehydes (e.g., Acetaldehyde), Ketones (e.g., Acetone)

  • Very reactive; important in building molecules.

  • Plays a role in energy-releasing reactions (metabolism).

  • Key in carbohydrates (especially ketones).

Carboxyl (-COOH)

Carboxylic acids (e.g., Acetic acid)

  • Acidic; ionizes in living tissues to form carboxylate ion (-COO-).

  • Participates in condensation reactions (protein formation).

  • Important in energy-releasing reactions (carbohydrate and fat metabolism).

Amino (-NH2)

Amines (e.g., Methylamine)

  • Basic; accepts a proton (H+), forming positively charged ammonium ion.

  • Participates in condensation reactions (peptide bond formation in proteins).

Additional info: Other important functional groups in biology include sulfhydryl (-SH), methyl (-CH3), and phosphate (-PO4), each contributing to molecular diversity and function.

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