Which of the following best describes the difference between reversible and irreversible enzyme inhibitors?

Irreversible inhibitors increase enzyme activity, while reversible inhibitors decrease it.

Reversible inhibitors can be removed from the enzyme, while irreversible inhibitors permanently inactivate the enzyme.

Reversible inhibitors are always toxic, while irreversible inhibitors are not.

Reversible inhibitors bind covalently, while irreversible inhibitors bind non-covalently.