Question 1

Which of the following best describes the role of SNARE proteins in vesicular transport?

Accepted Answer

They catalyze membrane fusion and provide specificity by forming a four-helix bundle between vesicle and target membranes.

Question 2

A mutation prevents the formation of COPII-coated vesicles. Which process would be most directly affected?

Accepted Answer

Transport of proteins from the ER to the Golgi apparatus.

Question 3

Which of the following is NOT a function of Rab GTPases in vesicular transport?

Accepted Answer

Catalyzing membrane fusion by forming a four-helix bundle.

Question 4

During clathrin-dependent endocytosis, which protein is responsible for pinching off the vesicle from the membrane?

Accepted Answer

Dynamin

Question 5

Which of the following equations correctly represents the energy requirement for SNARE complex disassembly by NSF?

Accepted Answer

$$ \mathrm{ATP} \rightarrow \mathrm{ADP} + \mathrm{P_i} $$

Question 6

A protein with a KDEL sequence is found in the Golgi. What is its most likely fate?

Accepted Answer

It will be returned to the ER via COPI-coated vesicles.

Question 7

Which of the following best describes the cisternal maturation model of Golgi transport?

Accepted Answer

Golgi cisternae move upwards and mature, being replaced by new cisternae from below.

Question 8

Which type of glycosylation links an oligosaccharide to a nitrogen atom on asparagine?

Accepted Answer

N-linked glycosylation

Question 9

A researcher observes that a protein is only able to leave the ER if it is properly folded. Which proteins are most likely responsible for this quality control?

Accepted Answer

Chaperone proteins such as BiP and calnexin

Question 10

Which of the following is NOT a method of protein transport through the Golgi?

Accepted Answer

Medial golgi transport

Question 11

Which face of the Golgi apparatus is responsible for receiving proteins from the ER?

Accepted Answer

Cis-Golgi

Question 12

Which of the following statements about vesicle coats is correct?

Accepted Answer

Clathrin-coated vesicles travel between the Golgi and plasma membrane.

Question 13

Which of the following is a direct result of terminal glycosylation in the Golgi?

Accepted Answer

Removal of carbohydrates from proteins.

Question 14

Which of the following is NOT required for vesicle fusion with a target membrane?

Accepted Answer

Adaptor proteins

Question 15

A cell is unable to recruit coat proteins to the membrane due to a defect in GTPase activity. Which process is most likely impaired?

Accepted Answer

Vesicle formation and budding

Question 16

Which of the following best describes the structure of the Golgi complex?

Accepted Answer

A stack of flattened membrane-enclosed sacs called cisternae

Question 17

Which direction does retrograde transport move proteins?

Accepted Answer

From the plasma membrane to the Golgi and then to the ER

Question 18

Which of the following is a real-life example of the secretory pathway in human cells?

Accepted Answer

Insulin being synthesized in the ER, processed in the Golgi, and secreted from pancreatic beta cells.

Question 19

True or False: Each Golgi cisterna matures by moving upwards through the Golgi.

Accepted Answer

True

Vesicular Transport and the Golgi Apparatus: Cell Biology Study Notes

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