Question 1

Which of the following DNA sequences could be the coding sequence for the peptide sequence N-Leu-Met-Arg-Trp-Ser-Ct?

Accepted Answer

5'-CTG ATG CGT TGG TCT-3'

Question 2

A gene has acquired a mutation in which the protein product has an extra 50 amino acids at the end. Which region of the gene was likely mutated?

Accepted Answer

Stop codon

Question 3

Which region(s) of a gene are NOT found within the mRNA transcript?

Accepted Answer

Promoter sequence

Question 4

A polycistronic mRNA contains multiple:

Accepted Answer

Coding sequences

Question 5

Which type of chromosome has no p arm?

Accepted Answer

Telocentric

Question 6

In balanced translocation heterozygotes, which pattern of chromosome segregation produces viable gametes and progeny?

Accepted Answer

Alternate segregation

Question 7

You wish to create a mutation in which you prevent access of RNA polymerase to the gene. Which region of a gene would you target?

Accepted Answer

Promoter sequence

Question 8

What is the consensus sequence for the Pribnow box from these sequences?
A. TUGTAT
B. TATAAT
C. TAGTAT
D. ACCAT
E. TAGTAT

Accepted Answer

TATAAT

Question 9

During translation initiation in prokaryotes, the amino acid on the initiator tRNA is:

Accepted Answer

Formylmethionine (fMet)

Question 10

A paracentric inversion differs from a pericentric inversion in that:

Accepted Answer

A paracentric inversion does not include the centromere

Question 11

Suppose a null mutation occurs in a gene. Which of the following best describes the effect?

Accepted Answer

The gene product is nonfunctional or absent

Question 12

Which of the following best describes a consensus sequence?

Accepted Answer

A sequence that represents the most common nucleotides at each position in a set of similar sequences

Question 13

Which of the following is true about crossover suppression in inversion heterozygotes?

Accepted Answer

Crossover suppression prevents equal exchange of chromosomes, resulting in loss of genetic material

Question 14

A mutation in the Pribnow box of a bacterial promoter is most likely to affect:

Accepted Answer

Transcription initiation

Question 15

Which of the following best describes the consequence of nondisjunction during meiosis?

Accepted Answer

Some gametes will have an abnormal number of chromosomes

Question 16

Which of the following is a real-life example of a balanced translocation in humans?

Accepted Answer

Philadelphia chromosome in chronic myelogenous leukemia

Question 17

If a gene is constitutively expressed, this means:

Accepted Answer

It is expressed at a constant level under all conditions

Question 18

Which of the following is NOT a consequence of a pericentric inversion?

Accepted Answer

Always results in gene duplication

Question 19

A mutation that changes a codon from UAU (tyrosine) to UAA (stop) is best described as:

Accepted Answer

Nonsense mutation

Question 20

Which of the following best describes the role of the Shine-Dalgarno sequence in prokaryotic translation?

Accepted Answer

It aligns the ribosome with the start codon on mRNA

Key Concepts in Transmission Genetics, Chromosome Structure, and Gene Expression

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