Ch. 26 - Population and Evolutionary Genetics

Klug - Concepts of Genetics 12th Edition

Klug12th EditionConcepts of Genetics ISBN: 9780135564776당신이 사용하는 게 아니라요?교과서 변경

Klug 12th Edition

Ch. 26 - Population and Evolutionary Genetics

문제 6b

26장, 문제 6b

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
0.000081

검증된 단계별 안내

Identify the given value as the frequency of individuals affected by the autosomal recessive disorder, which corresponds to the homozygous recessive genotype frequency $q^2 = 0.000081$.

Calculate the allele frequency of the recessive allele $q$ by taking the square root of the affected frequency: $q = \sqrt{q^2}$.

Determine the frequency of the dominant allele $p$ using the relationship $p + q = 1$, so $p = 1 - q$.

Calculate the frequency of heterozygous carriers (the carriers) using the Hardy-Weinberg formula for heterozygotes: \$2pq$.

Convert the heterozygous carrier frequency \$2pq$ into a percentage by multiplying by 100 to express the final answer as a percentage of the population.

비슷한 문제에 대한 검증된 영상 답변:

이 영상 해법은 위 문제에 도움이 된다고 튜터들이 추천한 것입니다.

영상 길이:

도움이 되었나요?

주요 개념

질문에 올바르게 답하기 위해 반드시 이해해야 하는 핵심 개념들은 다음과 같습니다.

Autosomal Recessive Inheritance

Autosomal recessive disorders require two copies of a mutated gene for the phenotype to appear. Individuals with only one mutated allele are carriers and typically do not show symptoms. Understanding this inheritance pattern is essential to relate genotype frequencies to disease prevalence.

Hardy-Weinberg Equilibrium

The Hardy-Weinberg principle provides a mathematical framework to relate allele and genotype frequencies in a population under random mating and no evolutionary forces. It allows calculation of carrier frequencies from disease prevalence using p² + 2pq + q² = 1, where q² represents affected individuals.

Calculating Carrier Frequency from Disease Prevalence

For an autosomal recessive disorder, the disease frequency equals q² (homozygous recessive). The carrier frequency is 2pq, where p ≈ 1 for rare alleles. By taking the square root of disease frequency to find q, one can estimate the percentage of heterozygous carriers in the population.

관련 실천

교과서 질문

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:

0.01

543

views

교과서 질문

The use of nucleotide sequence data to measure genetic variability is complicated by the fact that the genes of many eukaryotes are complex in organization and contain 5' and 3' flanking regions as well as introns. Researchers have compared the nucleotide sequence of two cloned alleles of the γ-globin gene from a single individual and found a variation of 1 percent. Those differences include 13 substitutions of one nucleotide for another and three short DNA segments that have been inserted in one allele or deleted in the other. None of the changes takes place in the gene's exons (coding regions). Why do you think this is so, and should it change our concept of genetic variation?

474

views

교과서 질문

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:

0.10

411

views

교과서 질문

The genetic difference between two Drosophila species, D. heteroneura and D. silvestris, as measured by nucleotide diversity, is about 1.8 percent. The difference between chimpanzees (Pan troglodytes) and humans (H. sapiens) is about the same, yet the latter species is classified in a different genera. In your opinion, is this valid? Explain why.

583

views

교과서 질문

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:

0.09

466

views

교과서 질문

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:

0.0064

464

views

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:0.000081

비슷한 문제에 대한 검증된 영상 답변:

주요 개념

Autosomal Recessive Inheritance

Hardy-Weinberg Equilibrium

Calculating Carrier Frequency from Disease Prevalence

Consider rare disorders in a population caused by an autosomal recessive mutation. From the frequencies of the disorder in the population given, calculate the percentage of heterozygous carriers:
0.000081