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Ch. 3 - Mendelian Genetics
Klug - Concepts of Genetics 12th Edition
Klug12th EditionConcepts of GeneticsISBN: 9780135564776당신이 사용하는 게 아니라요?교과서 변경
모든 교과서Klug 12th EditionCh. 3 - Mendelian Genetics문제 30b
3장, 문제 30b

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Assuming that Migaloo's albinism is caused by a rare dominant gene, what would be the likelihood of the establishment of a natural robust subpopulation of albino white humpback whales in this population?

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Understand the genetic basis of the problem: Albinism in this case is caused by a rare dominant gene. This means that an individual only needs one copy of the dominant allele (A) to express the albino phenotype. The normal phenotype is recessive (aa).
Consider the population genetics context: Since the albino trait is rare, the frequency of the dominant allele (A) in the population is likely to be very low. Use the Hardy-Weinberg principle to model allele frequencies and predict genotype frequencies in the population.
Set up the Hardy-Weinberg equilibrium equations: Let p represent the frequency of the dominant allele (A) and q represent the frequency of the recessive allele (a). The sum of allele frequencies is p + q = 1. The genotype frequencies are given by p² (homozygous dominant, AA), 2pq (heterozygous, Aa), and q² (homozygous recessive, aa).
Analyze the reproductive potential of albino individuals: Since albinism is dominant, both AA and Aa individuals will express the albino phenotype. However, the likelihood of establishing a robust subpopulation depends on factors such as the fitness of albino individuals, their ability to find mates, and the inheritance patterns of their offspring.
Evaluate the likelihood of a robust subpopulation: Given the rarity of the dominant allele (A), the initial frequency of albino individuals (AA and Aa) will be very low. For a robust subpopulation to establish, the allele frequency (p) would need to increase over generations, which could occur through mechanisms such as non-random mating, genetic drift, or selection favoring albino individuals. Assess these factors to determine the feasibility of a robust subpopulation.

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Genetic Inheritance

Genetic inheritance refers to the process by which traits and characteristics are passed from parents to offspring through genes. In the case of albinism, if it is caused by a dominant gene, only one copy of this gene is needed for the trait to be expressed. Understanding the principles of dominant and recessive alleles is crucial for predicting the likelihood of offspring inheriting specific traits.
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Diploid Genetics

Population Genetics

Population genetics is the study of genetic variation within populations and how these variations change over time due to factors like natural selection, genetic drift, and gene flow. In assessing the likelihood of a robust subpopulation of albino humpback whales, it is important to consider the genetic diversity, reproductive rates, and survival of individuals with the albino trait within the larger population.
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가이드 코스
03:45
Descriptive Genetics

Mutation and Phenotypic Expression

Mutation refers to changes in the DNA sequence that can lead to variations in traits, such as albinism, which results from a disruption in melanin production. The phenotypic expression of a mutation can be influenced by environmental factors and interactions with other genes. Understanding how mutations affect phenotype is essential for evaluating the potential for a stable subpopulation of albino whales, as it impacts their survival and reproductive success.
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가이드 코스
10:48
Mutations and Phenotypes
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교과서 질문

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Assuming that Migaloo's albinism is caused by a rare recessive gene, what would be the likelihood of the establishment of a natural robust subpopulation of albino white humpback whales in this population?

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교과서 질문

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. What data would be helpful in determining the answer to part (a)?

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교과서 질문

Albinism, caused by a mutational disruption in melanin (skin pigment) production, has been observed in many species, including humans. In 1991, and again recently in 2017, the only documented observations of an albino humpback whale (named 'Migaloo') were observed near New South Wales. Recently, Polanowski and coworkers (Polanowski, A., S. Robinson-Laverick, and D. Paton. (2012). Journal of Heredity 103:130–133) studied the genetics of humpback whales from the east coast of Australia, including Migaloo. Do you think that Migaloo's albinism is more likely caused by a dominant or recessive mutation? Explain your reasoning.

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