Question 1

Which of the following statements best describes enantiomers?

Accepted Answer

They are nonsuperimposable mirror images of each other.

Question 2

A carbon atom is considered a chiral center if it is bonded to:

Accepted Answer

Four different atoms or groups.

Question 3

Which of the following molecules is chiral?

Accepted Answer

$$\mathrm{CH_3CHBrCH_2CH_3}$$

Question 4

Why do only one enantiomer of a drug often have biological activity?

Accepted Answer

Because biological receptors are chiral and only one enantiomer fits properly.

Question 5

Thalidomide is an example of a drug where one enantiomer is therapeutic and the other is harmful. What property of thalidomide leads to this difference?

Accepted Answer

It contains a chiral center, resulting in two enantiomers with different biological effects.

Question 6

Which of the following best describes a chiral molecule?

Accepted Answer

A molecule that is nonsuperimposable on its mirror image.

Question 7

Given the molecule $$\mathrm{CH_3CH_2CHBrCH_3}$$, how many chiral centers does it have?

Accepted Answer

1

Question 8

Which of the following is NOT a consequence of chirality in pharmaceuticals?

Accepted Answer

Both enantiomers always have the same biological effect.

Question 9

Which of the following is true about the smell of oranges and lemons?

Accepted Answer

They are caused by different enantiomers of limonene.

Question 10

How do you identify a chiral center in a molecule?

Accepted Answer

Look for a tetrahedral carbon atom bonded to four different atoms or groups.

Question 11

Which of the following statements about mirror images is correct?

Accepted Answer

Some mirror images are nonsuperimposable, leading to chirality.

Question 12

A molecule with two chiral centers can have how many possible stereoisomers?

Accepted Answer

$$4$$

Question 13

Which of the following is a correct statement about the interaction of chiral molecules with biological receptors?

Accepted Answer

Only one enantiomer typically fits into a chiral biological receptor.

Question 14

Which of the following is the correct definition of a chiral center?

Accepted Answer

A carbon atom bonded to four different atoms or groups.

Question 15

If a molecule has a plane of symmetry, it is:

Accepted Answer

Always achiral.

Question 16

Which of the following is a real-world consequence of chirality?

Accepted Answer

The taste and smell of certain foods can differ due to different enantiomers.

Question 17

A molecule with the formula $$\mathrm{CH_3CH_2CH(Br)CH_2CH_3}$$ has how many chiral centers?

Accepted Answer

1

Question 18

Which of the following best explains why thalidomide caused birth defects?

Accepted Answer

It was sold as a racemic mixture containing both enantiomers, one of which was teratogenic.

Question 19

Which of the following is true about the relationship between chiral centers and enantiomers?

Accepted Answer

A molecule must have at least one chiral center to have enantiomers.

Question 20

Which of the following is the correct way to identify a chiral center in a structural formula?

Accepted Answer

Draw an asterisk next to the tetrahedral carbon bonded to four different groups.

Chirality and Enantiomers in Organic Compounds

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