Design a multifaceted intervention to reduce Lyme disease incidence in a suburban community that synthesizes reservoir and vector control approaches. Which combination of measures is most comprehensive and evidence-based?

Release large numbers of domestic chickens into suburban yards to consume all local ticks, and rely solely on this single intervention without resident education because chickens will eliminate the reservoir completely.

Focus only on vaccinating mice with an oral vaccine delivered in every backyard and ignore human behavior, deer management, and direct tick control measures because a single-host vaccination will eradicate ticks overnight.

Mandate universal antibiotic prophylaxis for all residents in spring regardless of exposure and discontinue vector control because antibiotics alone will prevent all Lyme cases.

Reduce deer and rodent habitat near homes through landscaping changes, apply acaricides in tick habitat and treat rodent reservoirs with bait boxes that reduce tick load, promote personal protective measures (repellents, protective clothing), and educate residents to check for ticks after outdoor activities.